I am 70. I had osteoporosis at age 48. Was unsuccessful with Fosamax due to GI effects. Did not start injection treatment until 57. Did Prolia w great success- no side effects and after 4 years had achieved increased bone density to osteopenia. My doctor kept me on Prolia for 12 years even though I had 3 breaks in the last 2 years. So I sought an osteoporosis specialist who told me you should have only been on Prolia for 6 years and then switch to another drug. So he started me on Evenity. First set of injections I just had leg fatigue, which I reported. 2 set within 48 hrs I had such extreme leg pain both legs from muscle contractures I ended up in the ER. They gave me Fentanyl, did blood work, and had a CT scan. Everything was normal except for a slightly elevated white count. I told my osteoporosis MD who seemed doubtful that it was the Evenity, but my husband, also a doctor said def the Evenity. So the next month I got an infusion of Reclast. I took ibuprofen before the infusion, the next day, and only the morning of the third day. By bedtime on the third day I was experiencing a lot of leg pain, both legs,and one arm. Ibuprofen helped. Then vole up this morning, the 4 th day at 5 am with a lot of leg pain. Ibuprofen helped, but very fatigued legs. I’m trying not to panic about this treatment as it’s the 4 th one I’ve done and there’s not much left. I’ve broken 9 bones since I was 48, and I don’t want my end years to be dreadful. I’m very active, healthy otherwise, and this has always been my biggest health issue. It was for my mother as well. I’m trying to put trust in this osteoporosis doctor. It’s difficult since other doctors have let me down. And very about long term side effects. Once a year infusion just sounds terrifying. Best wishes to everyone for healthy vibes