Soon to be 73 and have done surgery, 16 rounds of radiation for mop up - have been taking Antrolosa since last year when cancer was discovered in my lymph nodes - same estrogen positive breast cancer I had 30 years ago (had a mastectomy and tamoxifen). Yes noted the fatigue & had sleep issues - found the best way to deal with it was w/a short nap and kept walking even when I felt could not go on/very determined to not give up on the fresh air and sunshine. My oncologist prescribed a CDK4/6 - started on Verzenio 150MG twice a day to prevent reoccurrence, this is what knocked me physically down - ongoing digestion issues with diarrhea/horrible lower GI pain - these issues reoccurred often and often more intense. I know it sounds awful but worse issue surprised me/terrified me a little - the black mood the descended over me that I had never experienced in my life - friends said I was a changed person. I stopped Verzenio last week - one week off - 75% better but the side effects are still lurking so wondering if I can fully recover. Beware - the CDK 4/6 protelcal is very strong and may not be for all - I thought I was tough enough to tolerate - disappointed I could not tolerate.