I'm not talking systemic HRT, like Premarin. I'm talking about an estrogen cream that you apply vaginally. Very little, if any, is absorbed by the body so it's entirely safe for all women, even those with breast cancer. It's used simply to restore the shrunken, dried up tissues that occur with menopause, whether surgically induced via hysterectomy with ovary removal (like mine was 25 years ago) or natural. There are some available over the counter, but because they're not evaluated by the FDA, they aren't necessarily consistent with the estradiol content, whereas prescription estrogen creams are.