I've had PLMD for many years. Tried about a dozen different meds, some with really bad side effects. The only one that consistently works is Clonazepam. Small 2 mg. dose, before bed has been very successful for me. Docs don't like to prescribe, as it's highly addictive, & long term use may cause organ problems. I've been using for over 30 years, & have not had to deal with any probs. Clonazepam is used for anxiety & seizure disorders--PLMD is a seizure disorder. Good luck!