Hi @onekgguy, and welcome to Mayo Clinic Connect! It sounds like your knee replacement has been more than a bump in the road. I am glad you have been able to identify a source of discomfort, then able to discontinue Repatha injections. Hopefully your recovery will be in full swing now.

I see @unimon responded to you recommending you check out inclisiran. I certainly understand your exhaustion simply trying to live your life. I am in that boat with you! I can say after trying Repatha I have successfully had five injections of inclisiran. Finding a doctor to walk me through the process of figuring out “me” has been key.

I am curious what your prescribing doctor recommends. Have they discussed your unique risk factors with you?

Unimon, what do you know about inclisiran?