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Repatha, side effects and what comes next?

Heart & Blood Health | Last Active: 5 days ago | Replies (80)

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Profile picture for onekgguy @onekgguy

I was prescribed Repatha after too much joint and muscle pain while using Rosuvastatin (Crestor). I had been on the drug for about 8 months when I had total knee replacement surgery last November (7 months ago). My rehab has been very difficult with so much stiffness and swelling in my surgical knee. I decided to come off Repatha a month ago to see if I could lessen some of the swelling and joint stiffness. Just this past week I’ve begun to notice big improvements with how my knee responds to exercise. It’s not nearly as stiff and the swelling I had been experiencing in my knee joint is much diminished. I’m done with cholesterol meds as they’ve made my active lifestyle very difficult since beginning down this road a few years ago. My cholesterol level without meds is around 208. At 68 y/o I’m more concerned with the quality of my remaining years than in trying to squeeze out another year or two of life. At least I can say I tried.

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Replies to "I was prescribed Repatha after too much joint and muscle pain while using Rosuvastatin (Crestor). I..."

Hi @onekgguy, and welcome to Mayo Clinic Connect! It sounds like your knee replacement has been more than a bump in the road. I am glad you have been able to identify a source of discomfort, then able to discontinue Repatha injections. Hopefully your recovery will be in full swing now.

I see @unimon responded to you recommending you check out inclisiran. I certainly understand your exhaustion simply trying to live your life. I am in that boat with you! I can say after trying Repatha I have successfully had five injections of inclisiran. Finding a doctor to walk me through the process of figuring out “me” has been key.

I am curious what your prescribing doctor recommends. Have they discussed your unique risk factors with you?

Unimon, what do you know about inclisiran?

I totally agree with you ! I saw in this discussion group a Dr once said “what good is low cholesterol if you can’t get out of the bed in the morning”. That advise stuck with me !!