I've been taking low dose naltrexone for a little over a year now, and I've found it very helpful in keeping my pain manageable. I was diagnosed at one point with fibromyalgia. About 9 months ago, I had a skin punch biopsy, which ruled out Parkinson's but showed small fiber neuropathy. I'm now working with a neurologist at John's Hopkins Small Fiber Neuropathy Center, and further testing suggests an autoimmune disease. The constant for the last five years has been pain, at times completely debilitating.

My primary care physician is the one who suggested LDN; she'd had patients who found relief with it. It took about 3 months or so of playing with the doses to find the right one for me. I started at 2 mg/day, worked my way up to 4.5 mg/day, ending up back at 3 mg/day. I get the pills through a compounding pharmacy. The cost varies by pharmacy—$39/30 to $69/30—and insurance doesn't pay for it, but it's worth it to me. I ran out at one point, and the pain came back, so clearly the LDN makes a difference.

What I've found is that the naltrexone helps most with general pain. I still have to supplement with meloxicam and baclofen for flares of back pain, joint pain, etc. I take duloxetine, which is very helpful too, but I can't take gabapentin or pregabalin.

So many of these meds have different effects on different people, so there is always a process of trial and error involved. Reading up on LDN was very helpful to me. Here are some links to info I found useful:

Online Articles

LDN for Fibromyalgia
https://www.verywellhealth.com/low-dose-naltrexone-ldn-for-fibromyalgia-cfs-716070
LDN and POTS (Postural Orthostatic Tachycardia Syndrome)
https://pubmed.ncbi.nlm.nih.gov/37706146/
Drugs.com Overview
https://www.drugs.com/medical-answers/low-dose-naltrexone-ldn-3570335/
Pretty Technical, But Somewhat Helpful
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/
YouTube Videos

*Excellent Comprehensive Presentation on LDN

How LDN Works

Using LDN for Chronic Pain

Dr. Brandy Rose, Naturopathic Doctor, on LDN Pain Relief