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Therapy-resistant migraines

Posted by richardfrancine @richardfrancine, Feb 19, 2024

Hello everyone
I have been a migraine sufferer since the age of 8. I am now 77 and live with a headache 24/7 (except for the two days a week when my neurologist allows me one narcotic pill). I have tried every therapy in the book (betablockers, triptans, NSAID’s, botox, etc, etc…., including the latest meds out there- cgrp antagonists (aemovig, emgality, ubrelvy, and, so far, 3 infusions of Vyepti). NOTHING WORKS! Have any of you experienced this state of affairs and have you finally solved the problem? I am at my wits’ end. Thank you for any feedback!

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mikayla | @mikaylar | Jun 27, 2025

No migraine medicine has worked for me either and I have tried 'em all. 6 years now with this constant headache and dizziness. Doing PT now as my last hope.

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jrsjc | @jrsjc | Jun 27, 2025

I feel so bad for you. I'm 73 and have had migraines for 12 years with similar results with all medications. Qulipta worked for me as a preventative but caused severe constipation, so I dropped it. Any success I've had has been just luck. My dentist suggested an appliance to wear at night for snoring. He said it might help my migraines, and he was right. What really was (is) going on with me is sleep apnea. I skipped the CPAP machine and rely on the appliance. Now, I don't wake up with headaches anymore. If I get one they come later in the day. Also, I wear a cool patch that adheres to my forehead when I have a headache. It doesn't take the headache away, but numbs the pain whereby I can't feel it. Wearing the cool patch allows me to function. I also where one to bed. You can buy them on Amazon. They are called Well Patch for Migraines and Headaches. Good luck. Jim

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highlands1946 | @highlands1946 | Jul 11, 2025
In reply to @bobbi2 "I just turned 80 a couple of weeks ago; my migraines started in my 20's. I've..." + (show)
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I just turned 80 a couple of weeks ago; my migraines started in my 20's. I've suffered with them daily for 60 years and tried most drugs. The newer drugs on the market are out of my price range. The biggest help I've had is from changing my eating habits. All scratch cooking with organic foods. All the pesticides used on food triggered my migraines. I log my food and make note of foods that trigger headaches, I noticed pork as a trigger. Sugar is a HUGE trigger; I get a tad envious when I bake cinnamon rolls or cookies for my hubby and can't eat them. I'm currently on 10 mg of Amitriptyline and it's not working. I have an upcoming appointment, maybe he'll prescribe something I can afford.

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I wish I could find a year on your post. Not your fault.

Yes, SUGAR is huge trigger! Iam in your age bracket.

This week, I'm taking Prednisone to break the loop of returning headaches. 4-5 days at 100mg and not tapering off too soon. Start high or no effect.

I upped my Metformin to 1,500 mg a day which helps with the level of sugar in my bllod stream.

I added 100mg caffeine pill 2-3 times before the headache times arrive.

So far, so good. Had daily migraines for 2 plus months when I inadvertently stopped my preventative med Toprimate at a high dosage.

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