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Tamoxifen and blood pressure medication

Posted by gran71 @gran71, Jun 21 7:31pm

Are there any blood pressure medications that won’t interact with tamoxifen. My NP has prescribed at least 3 different blood pressure meds and I researched and found that all have the tendency to negate the benefits of tamoxifen. Help please!

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Mentor
Chris, Volunteer Mentor | @auntieoakley | 1 day ago
In reply to @cpleiva "Hi, Could you share where you can find info about what antidepressents work effectively w tamoxifen?..." + (show)
@cpleiva

Hi,
Could you share where you can find info about what antidepressents work effectively w tamoxifen?

Thanks,

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I found this paper from Harvard medical school.
There is a table at the bottom of this pretty short paper to give you options. I hope this helps.
https://womensmentalhealth.org/posts/clinical-update-2019-tamoxifen-and-antidepressants/
Are you taking tamoxifen now, with an antidepressant?

REPLY
gran71 | @gran71 | 1 day ago
In reply to @triciaot "@gran71 Ive been on tamoxifen almost 3 years and take losartan for blood pressure. Info I..." + (show)
@triciaot

@gran71 Ive been on tamoxifen almost 3 years and take losartan for blood pressure.

Info I found on the web, looks like losartan might improve the efficacy of tamoxifen, but a lower dose of losartan might be needed:
“While no direct drug interaction between losartan and tamoxifen has been identified, some research suggests a potential indirect effect. Losartan, an angiotensin II receptor blocker, may help overcome tamoxifen resistance in certain breast cancer cells according to the National Institutes of Health (NIH). This is based on studies showing that losartan can resensitize tamoxifen-resistant cells to tamoxifen treatment. Additionally, tamoxifen may affect the metabolism of losartan by inhibiting CYP2C9 activity, potentially leading to increased losartan levels.”

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Thanks for this information. I sort of considered this medication after researching alternatives. I will bring this up with my FNP and oncologist at my next office visit.

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