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Bone marrow biopsy and/or blood tests for MGUS

Blood Cancers & Disorders | Last Active: Jun 26 2:36pm | Replies (36)
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Profile picture for wesleym @wesleym

The study you reference is not yet complete, but the abstract of a 2024 interim report is at https://www.acpjournals.org/doi/10.7326/M23-2540

In many cases, it's not clear to me why a study of how blood tests may predict BMB results matters. For anyone in the gray treatment/nontreatment zone - me, for example - BMB results matter a great deal. Of course, any medical procedure has risks, but a BMB is quite safe. I for one would not accept a prediction in place of the actual result.

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Replies to "The study you reference is not yet complete, but the abstract of a 2024 interim report..."
dcuste | @dcuste | Jun 26 2:36pm

Thanks for the link. It appears that the study is using patients: 1043 persons with IgG, IgA, light-chain, and biclonal MGUS detected by screening and an interpretable bone marrow sample.
I have IgM MGUS with levels going up very quickly. I wanted to get a prognosis based on this calculator. https://awmrisk.com/index.html
I already have all the values except the % needed from a BMB. If I had a good way of estimating the BMB results, I would put off having the actual BMB until it was estimated to be over 10%.
I'm now guessing that since the study doesn't include any IgM people, the authors knew it wouldn't be applicable because maybe IgM people are looking at WM rather than MM.

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