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Polymyalgia Rheumatica (PMR) | Last Active: Jun 26 7:15am | Replies (17)
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When you say sustained remission, I am guessing that you mean no symptoms or do they do another biopsy to see if the disease is still there???
Ill ask to go to 10 mg from 15 mg since I am not having any real symptoms at 15.
Replies to "When you say sustained remission, I am guessing that you mean no symptoms or do they..."
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It was the terminology used in the GiACTA study that led to the FDA approval of Actemra for GCA in 2017.
"Remission was defined as absence of flare and normalization of CRP to < 1 mg/dL. A single CRP elevation (≥1 mg/dL) was not considered a flare unless CRP remained elevated (≥1 mg/dL) at the next study visit.
Sustained remission was defined as remission from Week 12 through Week 52 and adherence to the prednisone taper."
https://pubmed.ncbi.nlm.nih.gov/28745999/
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The IV formulation of Actemra was FDA approved for GCA in 2022.
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Long term use of Actemra is promising.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7359771
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I have been doing monthly IV infusions of Actemra for 4 years and I'm still in remission. I haven't had any serious side effects from Actemra. More importantly, I have been off Prednisone and I have mostly recovered from my Prednisone side effects.