I have had 6 Actemra infusions (one every 4 weeks). I have not had any side effects. The side effects from Prednisone were severe and prolonged. When I began my infusions, I was on 13 mg. day. Today, I am at 5. The Actemra has allowed me to step down 1 mg. every 2 weeks. I'm going to hold at 5 mg. until my rheumatologist appt. in mid-July. I've read that many people start getting side effects (pain/fatigue) from the lack of pred. Could be a cortisol situation. Overall, I am very pleased with the progress I have made and lack of side effects.