I'm at six months on Orgovyx and after 44 radiation treatments, with Gleason 4+3 and N1M0, iliac lymph nodes and latest PSA 0.01, testosterone 0. I'm campaigning with my oncologist to switch to a similar drug, Darolutamide, after one year. I've met a gentleman online who has used Darolutamide alone since August. Latest Testosterone 1100, PSA undetectable, former lymph node activity also undetectable. His Dr. Hugec in Minnesota has reportedly 20 patients on this monotherapy. I too have experienced every Orgovyx side effect with fatigue being the major daily issue. Exercise helps some: I had an unrelated surgery recently and without daily exercise, fatigue has been really slamming me. Darolutamide/Nubeqa seems to have lesser influence on fatigue, brain fog, and heart issues. By switching, I'm hoping to lessen side effects and prevent the cancer becoming castrate resistant.