I've been thinking I need to write to you to see how you are doing. Did you try the Naliri chemo treatment yet?

I'd hate to see you get phase 2, when researchers are already on phase 3. Naliri is the chemo drug you could get if you don't get the actual 6236 med. Ask the study oncologist if they could ensure you get Naliri if you don't get the actual drug. I myself can't tolerate Naleri, but that's only due to my underlying breathing and underlying problems; but it's an effective defender based on what other members are posting.

RMC-6236 is showing consistently promising results. There are a number of trials for this pan-KRAS inhibitor with a good safety profile and the progression-free survival encouraging. I too would prefer entering a phase II trial as the safety profile is already established and everyone in the trial receives the drug at the dosage established in the phase I trial. I’d only consider a phase III trial when there was no other option but a remaining standard of care.

I was in a phase II trial eleven years ago and here I am 13 years later after a diagnosis of stage IV and considered cured. I can say plenty about enrolling in a phase II trial.