I have been on Orgovyx for last two months.

I have seen it happen, but usually it’s with a lower PSA. What was your PSA When you started Orgovyx ? It could be you are castrate resistant to start. Next step would be an ARSI drug.

You might ask them to try a different ADT first. Orgovyx is an LHRH Antagonist; Eligard, Lupron, etc. are LHRH Agonists and work through a different mechanism.

Talk to your doctor. In six weeks on Orgovyx, my PSA had dropped 50%.

Hi @betterhealth2 ,

My PSA in March 2024 was 7.9, in June 2024 I was diagnosed with Gleason 8 PCa. I started on Orgovyx in early October 2024. I meant to get a baseline Testosterone reading before I started the Orgovyx but I messed up on the scheduling and got the Testosterone blood draw on my 4th day of Orgovyx. My Testosterone result was 18; the drug either worked very fast for me or I started Orgovyx with an already low Testosterone level. About 11 weeks later, one week before I started my 28 fractions of IMPT, out of curiosity I had a PSA test. The result was 0.42.

A couple weeks ago I had my first PSA and Testosterone tests at 4 months post-radiation. Results: PSA < 0.04 (Quest Diagnostics, considered undetectable), Testosterone = 23.

Would you mind sharing your PSA level before and after starting Orgovyx? Also, regarding Testosterone levels, these can bounce around quite a bit. Even the time of day of the test is a factor, along with your activities preceding the Testosterone blood draw.

Also, remember that it is important that you take your Orgovyx every day, at close to the same time. The in situ half-life of a 120 mg dose of Orgovyx (relugolix) refers to the time it takes for the drug concentration in the body to decrease by half during its presence and action at the site (i.e., within the body), which is effectively described by its pharmacokinetic half-life.

For relugolix, the mean effective half-life is 25 hours, while the mean terminal elimination half-life is approximately 60.8 hours. The effective half-life (25 hours) is most relevant for clinical dosing and steady-state considerations, whereas the terminal half-life (about 61 hours) describes the final, slowest phase of drug elimination from the body.

Best of luck to you!

My doctors have recommended Orgovyx in combination with Nebeqa or another testosteron deprivation drug like Xtandi. They said the combos are now being used all the time, Ask your doc about this.