The support people at Onco360 pharmacy told me that Besremi can withstand temperatures of up to 77°. There have been times that it arrived at my home barely colder than room temperature and it was ok. If I were traveling with Besremi for just a few hours I would put it in a ziplock bag with a couple of cold packs right out of the freezer. What kind of documentation do you need for traveling with Besremi on a plane?