Letrozole and Neuropathy

I was on Letrozole for 9 months before chemo. The only side effect I had was hot flashes. My neuropathy is chemo induced and improved somewhat after chemo finished. I'm off Letrozole in two months and looking forward to some (hopefully) real improvements in the next year. I'm also transitioning off Prolia which I think may be sharing the blame for a lot of my joint issues. I'm blaming Letrozole (or any AI, I've been on all 3) for insomnia, brain fog, elevated lipid levels, moodiness, inability to lose weight, and probably more. But after the initial improvement of my neuropathy after finishing chemo (about a year), my neuropathy has worsened only slightly in the last year. (I finished chemo 4 years ago).

I find no matter what your status of dealing with breast Cancer is, there is always something in the wind that might give you some definition or clarity.
After currently being on a 3 week hiatus from Anestrozole because of side effects, I was so hopeful to find a reasonable alternative to offer in my upcoming phone conference with my nurse oncologist on this coming Monday.

My side effects were/are worthy of my challenge to continuing on this Anestrozole path. In another medical related visit this past week my mention of my side effects were each delicately suggested as a random result of everyday maladies.
It was as if part of the success of AI relied on making my brain simply absorb this dose of logic rather than simply consider it in my collection of information. I gratefully accepted this feedback but filed it in my brain as more of the - Bengay/Tylenol Approach to AI Side Effects - that carry as much weight as YOU deem them of value.

Below I am sharing a Clinical Study that might deserve a space in your consideration. I will certainly bring it up for discussion on my Monday call.
https://www.nature.com/articles/s41416-019-0435-4

I know my response is months late, but I had exactly the same experience. 3 days after starting Letrozole, my heretofore insignificant neuropathy, which was only in my toes and fading, significantly worsened to involve the bottoms of my entire foot, my hands, and my balance. My doc's nurse told me it is "unlikely" that it was the Letrozole after only 3 days. I wrote back and said, okay, assuming it's not the Letrozole, I've still got the problem and what could be causing it? I went through this with the steroid infusion, told for weeks that my 3 days of horrible symptoms, including 72 hours of night sweats, were depression. That is stupid on its face. I also was not warned about the ethanol in the docetaxel solution, and had to figure out on my own that I was drunk after being sober for 13 years. Fortunately, my husband always drove, but involuntary intoxication is a defense to drunk driving or, God forbid, killing someone with your car. Your oncologist or hospital will have no such defense. Oncologists are shocked -- shocked! -- by the breast cancer patient experience. Frankly, I'm disgusted that they're shocked. Did they listen to their patients at all during the 20-30 years they were practicing oncologists before breast cancer happened to them? The oncologists are also shocked when they are not listened to, either. Some of those oncologists try to monetize their experience by starting Youtube channels and writing books. They think, since they're oncologists, they're uniquely positioned to explain the things that happen to all of us.

I believe neuropathy may be hereditary as well. My mom had it but later in life. I’m 59 and she didn’t have it til about 80. I was thinking the Letrazole May have triggered it. I came off of it and am currently not taking any meds. Thanks for your reply.

I experienced an increase in the severity of my neuropathy while in Letrozole. I took a break for 3 weeks and it did help. The neuropathy in my feet got better. I’ve been taking Letrozole again for a little over a month and my neuropathy is ok. My oncologist didn’t think there was a correlation but I believe there is.