Newest and best long covid recovery treatments?

I just saw this new research published in Nature. This may give doctors new pathway to help patients.

A Nature study published in June 2025 by Australian scientists revealed that in patients with severe COVID-19, the delicate lining of blood vessels, called endothelial cells, starts to break down when oxygen-rich blood cannot reach tissues. This breakdown of endothelial cells, potentially triggered by COVID-19 infection, causes immune signals that lead to red blood cells bursting and releasing sticky contents into the bloodstream. This “glue-like” material can clog the smallest blood vessels (capillaries), blocking circulation and causing tissue damage in organs like the kidneys, liver, and heart.

Interestingly, the researchers were surprised to find no widespread fibrin and clotting in analyzing patient samples, which was initially expected. Instead, they found that the microcirculation issues were primarily due to the debris from broken red blood cells. This suggested a novel mechanism of vascular damage in COVID-19 through the death of endothelial cells, which had not been previously considered. The study highlights that this microvascular damage and broken red blood cell issue were significant problems in the microcirculation of COVID-19 patients.

This research suggests that targeting the death of these vessel-lining cells could be a potential strategy to combat COVID-19 symptoms and long COVID, potentially requiring a combination of treatments. These findings may also impact our understanding of other conditions like stroke and heart attack where standard treatments are not effective.

I just saw this new research published in Nature. This may give doctors new pathway to help patients.

A Nature study published in June 2025 by Australian scientists revealed that in patients with severe COVID-19, the delicate lining of blood vessels, called endothelial cells, starts to break down when oxygen-rich blood cannot reach tissues. This breakdown of endothelial cells, potentially triggered by COVID-19 infection, causes immune signals that lead to red blood cells bursting and releasing sticky contents into the bloodstream. This “glue-like” material can clog the smallest blood vessels (capillaries), blocking circulation and causing tissue damage in organs like the kidneys, liver, and heart.

Interestingly, the researchers were surprised to find no widespread fibrin and clotting in analyzing patient samples, which was initially expected. Instead, they found that the microcirculation issues were primarily due to the debris from broken red blood cells. This suggested a novel mechanism of vascular damage in COVID-19 through the death of endothelial cells, which had not been previously considered. The study highlights that this microvascular damage and broken red blood cell issue were significant problems in the microcirculation of COVID-19 patients.

This research suggests that targeting the death of these vessel-lining cells could be a potential strategy to combat COVID-19 symptoms and long COVID, potentially requiring a combination of treatments. These findings may also impact our understanding of other conditions like stroke and heart attack where standard treatments are not effective.

I just saw this new research published in Nature. This may give doctors new pathway to help patients.

A Nature study published in June 2025 by Australian scientists revealed that in patients with severe COVID-19, the delicate lining of blood vessels, called endothelial cells, starts to break down when oxygen-rich blood cannot reach tissues. This breakdown of endothelial cells, potentially triggered by COVID-19 infection, causes immune signals that lead to red blood cells bursting and releasing sticky contents into the bloodstream. This “glue-like” material can clog the smallest blood vessels (capillaries), blocking circulation and causing tissue damage in organs like the kidneys, liver, and heart.

Interestingly, the researchers were surprised to find no widespread fibrin and clotting in analyzing patient samples, which was initially expected. Instead, they found that the microcirculation issues were primarily due to the debris from broken red blood cells. This suggested a novel mechanism of vascular damage in COVID-19 through the death of endothelial cells, which had not been previously considered. The study highlights that this microvascular damage and broken red blood cell issue were significant problems in the microcirculation of COVID-19 patients.

This research suggests that targeting the death of these vessel-lining cells could be a potential strategy to combat COVID-19 symptoms and long COVID, potentially requiring a combination of treatments. These findings may also impact our understanding of other conditions like stroke and heart attack where standard treatments are not effective.

Hi Janetbender, I’m Kelly.
I am sorry to hear of the
essential Thrombocytosis. Blood cancer, correct? Covid has been awful for many of us. If you don’t mind me asking, what were your symptoms and what type of Dr diagnosed it? I have seen a few people mention POTS as well. My cardiologist, on my first visit to her, said POTS and handed me a piece of paper with info on it about POTS, and was done with me. I fired her then and there. She never even tested me. My heart rate is raised from any type of movement. Even showering. I’m fighting to get any true diagnosis besides long Covid. Treating me for ME (like fibromyalgia) with new drugs. Take 18 medications now from long Covid. Do they have you on all kinds of meds? Is the Fludrocortisone for Congenital adrenal hyperplasia? I am wanting to compile a list of diagnoses from people to get an idea if any are a like or a pattern. I’m in limbo. I have all symptoms leading to CHF (congestive heart failure) but my tests say differently. Or possibly PH (pulmonary hypertension) but I’m on low end so the true test there is right heart cath. Now thinking Cushings Syndrome and waiting for an Endocrinologist appointment my new cardiologist is sending me too. Meanwhile I get worse with no reasoning for it. Trying to see what others are experiencing. All chime in. Want to try and see what others experience.

You are Like me with one of the more major symptoms of LC being heart/ circulation related. High Bp were my first obvious symptoms after Covid had gone back in April 2020, with high HR following…no ecg, echocardiogram, chest X-ray etc showed any obvious problem but I was finding it more and more difficult to walk ( having been an assiduous 10,000+ steps a day sort) or even small domestic tasks like standing brushing my teeth or cooking on a stove without pain and breathlessness. Gp had me on 5 hypertensive drugs, and that was it. I tried more self treatment: been swimming last 18 months 5x a week, and at same time intermittent fast 16 hours…no obvious difference, but surely done me some good , even if only mentally! Then I insisted on getting referred to a Falls specialist 2 hours drive away to get a tilt table test, thinking I self diagnosed with PoTS. The week before the test I had a complete collapse out cold in town, followed by dramatic vomiting. The test showed I had postural hypotension, after 8 mins BP had dropped from hyper to 60/40, and specialist insisted my high HR was due to it compensating for this drop…definitely not PoTS. But similar treatment, minus extra salt, with compression socks etc. Meanwhile my GP is also trying to do his bit putting back BP drugs the Falls expert had removed, and tampering with my hormone replacement on my 24 year old hypothyroid diagnosis ( insisting high HR is from ‘overmedicating on levothyroxine’), but that’s another story. It’s depressing how so few doctors seem to know about LC, mine admitted ‘wasn’t interested’ so presumably in Uk others just trying th3 self medicating etc using support of forums like this!

Please look up Dr Jordan Vaughn on the internet. He has done wonderful things with long term COVID and does a lot thru mailings. He's even testified before Congress on issues relating to long term COVID.