I take HU daily 500mg every night before bed. I sleep okay, but often have some leg cramps. The worst fatigue doesn't hit me until around noon the next day. Afternoons are hardest. I have extreme exhaustion by late afternoon, alleviated by eating an early dinner. I'm also on Levothyroxine (complete thyroidectomy) that I take first thing in the morning. I think that's why my mornings are so manageable; then that dose wains by afternoon.
Yes, HU has caused much fatigue and some annoying hair thinning. I take Essential Amino Acids, Biotin and my daily vitamin in the mornings. I;m 73, ET diagnosis with Jak2 and other mutations lurking (TET2, ASXL1).
Any suggesions to avoid the extreme exhaustion are appreciated. I'm hoping for a reduced dose of HU, since it is doing the job of lowering my platelets (last check was 384).