When I was diagnosed with ET, I knew from my Dad's experience that meds would be in the cards in a few years. After reading up on HU and anagrelide, the only treatments at that time, my first choice was anagrelide. But I discussed both HU and anagrelide with my cardiologist. I have mitral valve prolapse with regurgitation, and he said that anagrelide could cause abnormal heart rhythm. He said the HU would be a better choice for me heartwise.

Some people love anagrelide and it works good. Some people have bothersome cardiac symptoms with it. We're all different.