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Suzetrigine - a novel drug for pain

Chronic Pain | Last Active: Jun 28 4:36pm | Replies (262)

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Journavx is being marketed for acute (short-term) significant pain. Classic instance would be surgery for broken bones, etc. The phase 2 trial was apparently equivocal, & even it only sought short-term benefit for acute pain. NOT chronic pain.
Severe stenosis? Sorry: they won't be applying for that kind of application until at least after a Phase 3 trial for acute pain.
That doesn't mean your MD can't apply to use it off-label for chronic pain, especially under the Compassionate Care Act if you qualify. But again, that won't likely be a possibility until after a Phase 3 trial reports. That's a few years away, best case.

I do expect there'll be a rush of requests for off-label use, & suspect the pharma company is counting on that. Doctors are under tremendous pressure to reduce their prescription of opioids; patient demand for non-opioid pain meds that work is enormous. I'm sure the pharma company realizes it's sitting on a golden goose & they'd better not F it up by rushing to market, appearing to too obviously game the approvals process, or look too greedy.
If this stuff is relatively side-effect free, not too expensive and actually IS as effective as opiates, there's not only a Nobel prize in store for them, it'll be the blockbuster of the century.

I'm not them - especially not their lawyers - but I'd argue for speedy approval to provide under the Compassionate Care Act free or at very affordable price, on condition that all such use be tracked & outcomes reported meticulously. Such a process would tell the FDA more than even a large Phase 3 trial while demonstrating compassion & concern for patients. And should demonstrate just how amazing such a drug is. They could even supply it free: this kind of program would create more and better data than a Phase 3 trial at a tiny fraction of the cost. No way would such a program cost $20-30 million, and that's the cost of an ineffectually-small phase 2 trial today. A bargain! All while generating market awareness & demand - advertising-free - and generating enormous goodwill. A bargain!

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Replies to "Journavx is being marketed for acute (short-term) significant pain. Classic instance would be surgery for broken..."

Its available 600 dollars without a plan actually 500 something

Not sure if that would touch the bone pain I have with these WBC booster shots I get after chemotherapy. I already take hydrocodone for severe back issues and the ER morphine 15mg every 12 hours. As soon as my treatments end I'll stop the morphine. I had chemo on the 9th, Monday, and the bone pain starts about 2 days after and lasts about 5 days. It did with my 4th treatment. Both legs hurt from groin to ankles. If I knew without a doubt this new med would treat my pain, I might try it. I've been on hydrocodone for 20 years though. It still works as it did when I started it. I take it every 6 hours, every 4 when I need it but that's only about once a month. This bone and cancer pain is horrible though so I'd need something I knew worked without risking my sanity. Lol