Metformin side effects

Posted by naiviv @naiviv, Aug 3, 2024

Hello everyone. I have been taking Metformin 500mg for one month now and I have noticed that my Digestive System is acting up, I never had issues before. Also I am experiencing mood swings like never before. I am 72 so I am long pass menopause. Have you noticed any side effects? Thznk you. Vivian N

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@scottrl

I've been taking metformin for years. I can tolerate 500mg x 2 daily, but beyond that and I have trouble.
Here's a thought:
Take 250mg x 2 daily. (Break the 500mg tablets in two.) One after breakfast, one after dinner.
See if that helps.
Good luck!

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Thank you.

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@naiviv

I have been taking Metformin 500mg once a day since Sept 2024. At the beginning I had some GI issues but I attributed to having oatmeal evetyday for breakfast. Now after 4months I decided to make an experiment by stopping oatmeal to see if my GI issues were caused by it. Well I still have them and even very soft stools, diarrhea in the morning ( I take Metformin after breakfast). Has anyone of you who ate taking Metformin or have taken it have diarrhea and active growling in the intestines? If you stopped it which medication got you better. It is a real nuisance believe me. I have to stay all morning at home until the growling of my intestines and the urge to go to the bathroom are completely gone.
My PCP told me that I have A1C of 6.5 with a blood sugar of 92. I am following a strict Mediterranean diet and exercise everyday. If anyone has any information I would like to know. Thank you in advance.

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@scottrl that suggestion has potential but we members here should not be prescribing or making dose adjustments suggestions to fellow members. It sounds like what you are doing works well for you. @naiviv could you run Scott’s idea by your provider before trying it? All meds have side effects. If you don’t adjust to them, your provider can adjust the dose or perhaps suggest something else that you can tolerate better. Your A1C and blood sugar sound really good. Congrats on the diet and exercise.

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@naiviv

I have been taking Metformin 500mg once a day since Sept 2024. At the beginning I had some GI issues but I attributed to having oatmeal evetyday for breakfast. Now after 4months I decided to make an experiment by stopping oatmeal to see if my GI issues were caused by it. Well I still have them and even very soft stools, diarrhea in the morning ( I take Metformin after breakfast). Has anyone of you who ate taking Metformin or have taken it have diarrhea and active growling in the intestines? If you stopped it which medication got you better. It is a real nuisance believe me. I have to stay all morning at home until the growling of my intestines and the urge to go to the bathroom are completely gone.
My PCP told me that I have A1C of 6.5 with a blood sugar of 92. I am following a strict Mediterranean diet and exercise everyday. If anyone has any information I would like to know. Thank you in advance.

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Thanks. I will.

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I just started Metformin 2 days ago 500 mg twice a day morning and night, I had aspiration pneumonia and I was on prednisone for about 4 months 50 mg a day and it made me a diabetic, I noticed it gives me a lot of body pains and a really bad headache, is that common? I don't have any stomach symptoms at the moment.

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@jllamas

I just started Metformin 2 days ago 500 mg twice a day morning and night, I had aspiration pneumonia and I was on prednisone for about 4 months 50 mg a day and it made me a diabetic, I noticed it gives me a lot of body pains and a really bad headache, is that common? I don't have any stomach symptoms at the moment.

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All meds have side effects. Metformin is no different. All potential side effects must be reported in the drug information. It is good to be aware before starting a med. you may or may not experience the side effects. If you do, you may adjust to them over time. If not, a dose adjustment by your provider can help. Or there could be an alternative med that is better for you. Don’t give up. You aren’t alone. I’m sorry for the prednisone causing diabetes. steroids are a common cause of increased blood sugar. My hopes and prayers for you are that things will start to settle for you. Make sure these responses get accurately recorded in your medical history so that you get the best care moving forward.

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@jllamas

I just started Metformin 2 days ago 500 mg twice a day morning and night, I had aspiration pneumonia and I was on prednisone for about 4 months 50 mg a day and it made me a diabetic, I noticed it gives me a lot of body pains and a really bad headache, is that common? I don't have any stomach symptoms at the moment.

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Sorry for what you’ve been through. Metformin can cause stomach issues. I started it last year taking only one tablet a day and at the beginning I had stomach issues but these have faded with time. Every person is different and I have heard of people taking it without any issues. Prednisone increases glucose in blood dramatically and weakens the immune system. Hope you get better.

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Because I am an Alpha1 Anti-trypsin carrier, MZ, affecting the liver, metformin built up to a toxic level and Glipizide caused my heart to race at 115 for weeks after I came off it. Januvia dropped kidney function from 64 to 44, which I gradually brought back to 59 over a year. Initial digestive problems are common, but watch out for hand tremors, racing heart or higher blood pressure. Know the signs of liver toxicity or acidosis. If the problem persists ask for genetic testing for liver function. I had to go on insulin.

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@semicolon

Because I am an Alpha1 Anti-trypsin carrier, MZ, affecting the liver, metformin built up to a toxic level and Glipizide caused my heart to race at 115 for weeks after I came off it. Januvia dropped kidney function from 64 to 44, which I gradually brought back to 59 over a year. Initial digestive problems are common, but watch out for hand tremors, racing heart or higher blood pressure. Know the signs of liver toxicity or acidosis. If the problem persists ask for genetic testing for liver function. I had to go on insulin.

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Are you a prediabetic patient? I am. I stopped yesterday Metformin to check if it is causing my digestive issues and still I have some but I was taking Myralax daily and stopped it too. I don’t feel sick but my fasting BS in am has increased from 98 which was my normal to 111. I will keep checking my BS for a few days more as my PCP recommended it and depending how I feel I will go ahead and start Metformin because I don’t think it was the cause of my GI issues. The acidosis is what I fear with Metformin but I am taking only one tablet after breakfast. Thanks for your input. Stay healthy.

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If you are dealing with several different conditions, treatments &/or medications things can quickly become complicated. This is why I would be very hesitant to start, stop or make dose changes without input from a provider who knows my whole medical history. Your provider knows of potential interactions that can occur when you are adjusting to a med or treatment change. S/he can also help you prioritize the steps and timing of changes you want to consider. You don’t want to change too many things at one time because it will be harder to evaluate the results.

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