My go-to activity when I'm feeling depressed id to try and encourage others. (I was disabled by a stroke, and I have very limited mobility.)

It gives me something positive to do, helps others, and typically reflects positively back on me.
I have a video about this on my YouTube channel:

Another thing: I have found that my depression can be suppressed anger. I examine my conscience for things I'm angry/frustrated about, then make a list. That helps me defuse the depression.

Good luck! There are ways to deal with depression besides medication, I've found.