Novel Drug Candidate VOMG

Posted by melissaf @melissaf, Jan 27 5:17pm

Greetings!
Does anyone have information regarding VOMG, "a drug-like molecule active against Mycobacterium abscessus"? I found an article published in the International Journal of Antimicrobial Agents, Volume 64, Issue 4, dated October 2024. I am not a scientist so do not understand all the research data, but the article states that VOMG inhibits "cell division with broad-spectrum activity against other microbial pathogens" and has success in vitro, in vivo and biofilm. This study was performed in Milan.
This article gives me hope, although, years down the road to market.

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

judilynn2 | @judilynn2 | Jan 28 10:40am

I read so much about keeping your airways clear. I use the PEP aparatus but what are other ways to keep your airways clear. I nebulize 3.5% sodium too.

sherrig | @sherrig | Jan 28 2:57pm

Following also interested in this Novel Drug Candidate

Sue, Volunteer Mentor | @sueinmn | Jan 28 4:29pm

In reply to @sherrig "Following also interested in this Novel Drug Candidate" + (show)

We are all interested - the bad news is, this is a VERY preliminary report based on non-human testing (test tubes and lab animals.) There are several years of experimentation, followed by 2 phases drug testing of testing on humans before we might see it on the market.

kathyjjb | @kathyjjb | Jan 29 11:38am

I found a fairly non-technical summary of the study online, written by Cystic Fibrosis News. I just googled VOMG and Mycobacterium Abscessus or MAC Abscessus and it was one of the articles that popped up. The dosage seemed shockingly high but apparently the mice bodies cleared it. Hard to get feedback from mice. Sounds like if the human studies are successful, it could take 10 years to get to market. Though, nice to hear that it was a study for M. Abscessus vs MAC treatment.

kathyjjb | @kathyjjb | Jan 29 11:47am

In reply to @judilynn2 "I read so much about keeping your airways clear. I use the PEP aparatus but what..." + (show)

Sue (volunteer mentor) posted an excellent video of Dr Pamela McShane discussing airway clearances. Her recommendation is 7% saline followed by breathing exercises. This information should be in every Pulmonary Clinic. I have had such a hard time producing sputum and following Dr. McShane's recommended procedures has been life changing. I am coughing less, my airways feel clear, etc. She also referenced a UK study with 100 participants, 55 tested positive for MAC or someother bacterium and at the end of the 1 year study, nebulizing 6% saline, only 15 tested positive for MAC.

wabashacabin | @wabashacabin | Feb 2 6:18am

In reply to @kathyjjb "Sue (volunteer mentor) posted an excellent video of Dr Pamela McShane discussing airway clearances. Her recommendation..." + (show)

Where is the link to her video please♥️

melissaf | @melissaf | Feb 2 3:38pm

Try copy and pasting this: https://www.youtube.com/watch?v=L-EHohMe7II

mferrier1030 | @mferrier1030 | Jun 8 5:24am

Have you started a clinical trail yet? If so, my husband has been fighting with this bacteria for over two years. He was giving 2-6 weeks to live on January 3, 2024 and he is still with us. He is a fighter, so he would love to enter a clinical trail when one is available. Thank you.

Sue, Volunteer Mentor | @sueinmn | Jun 8 10:02am

In reply to @mferrier1030 "Have you started a clinical trail yet? If so, my husband has been fighting with this..." + (show)

There seems to be no further information available yet. Here is a link to the original article from 2024:
https://www.sciencedirect.com/science/article/pii/S0924857924001961#abs0001
Given your husband's dire situation, perhaps you or his doctor would like to contact one of the authors to inquire about current status. If you look at the list of authors, those whose email addresses are available are indicated by a small envelop icon next to their names.

You may also want to do some research about whether there is any news about phage therapy, especially for what is called "compassionate use", that is as a last resort.

Best wishes to both of you, he sure is a fighter!

mferrier1030 | @mferrier1030 | Jun 10 5:29am

In reply to @sueinmn "There seems to be no further information available yet. Here is a link to the original..." + (show)

Thank you for this information. We are working with Jefferson's doctors (pulmonary and infectious disease), so I will share this information with them. Thank you again.