Signatera test at 2 years remission, worth doing?

Posted by CObcHowdy @nbthowdy, 4 days ago

A little history:
Aug 2022- Diagnosis of bilateral IDC breast cancer, HR+, HER2-, ki67 @ 19%, Grade 2 on left, Grade 1 on right.
Aug 2022- Bilateral lumpectomy and all armpit nodes removed, both sides. 1 left LN had cancer—Oncotype of left= 23, Oncotype of right = 11.
Sept 2022-Nov 2022- 4 rounds of T/C chemo.
Nov 2022- Started Letrozole
Nov 2022- Started monthly Lupron injections.
Nov 2022- CT with contrast- "NED"
Nov 2022- Cancer antigen test 43 (same day as last chemo infusion)
Dec 2022- Bilateral mastectomy with reconstruction (my choice on both), no cancer in any tissue.
Feb 2023-Apr 2023- 5 weeks of radiation on left= chest, breast, armpit, and neck.
May 2023- started bi-annual Zometa infusions to strengthen bones.
June 2023- Removal of both ovaries/tubes, stopped Lupron.
Oct 2023- Breast cellulitis, emergency surgery to remove implants
June 2024- Diep flap surgery
Tuesday, 6/3/25 - will be my 6-month labs, exam, and Zometa infusion. I asked for the Signatera blood test because waiting around for the other shoe to drop sucks. I like to know everything.
Note: I was 47 at the age of diagnosis. My mother, 68 at the time, was diagnosed with the same bc 3 weeks after me. Our genetic testing came back negative. In 2020, we both started getting testosterone pellets every 3 months. In 2023, my oncologist ordered the ingredients of the pellets. There was testosterone AND estradiol in them. My mom and I got the pellets at the same place. When I was first diagnosed by the breast specialist/ radiologist in August 2022, she asked me who my doctor was, and I mentioned the name of the doctor who gave me the pellets. The radiologist replied, "Oh yes, I know her, I have her on speed dial!" Very strange.

I would like to hear thoughts from anyone who has done the Signaterra test with a similar history to mine. I'm afraid that if it's positive, I will lose my mind.

Interested in more discussions like this? Go to the Breast Cancer Support Group.

You give a very detailed history. Let me just say I am 71 and was first diagnosed at 32 and have had radiation, chemo, 2 separate mastectomies surgery to my chest wall, lymph node surgery, cyberknife. I have been NED for the past 3 years & have had Signateta every six months for the past 2 years and am extremely grateful to do that rather than continued PET/ CTS. So worth it in my opinion.

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Good news! My first CTDNA test came back negative! Yay!

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@roseann4z

You give a very detailed history. Let me just say I am 71 and was first diagnosed at 32 and have had radiation, chemo, 2 separate mastectomies surgery to my chest wall, lymph node surgery, cyberknife. I have been NED for the past 3 years & have had Signateta every six months for the past 2 years and am extremely grateful to do that rather than continued PET/ CTS. So worth it in my opinion.

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Thank you! Did your bc come back 3 years ago?

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First for me was 1998, second in 2014 and metastasis to lung 11/22.

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That must be rough. I'm so happy you are getting negative results!

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@nbthowdy

Thank you! Did your bc come back 3 years ago?

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It has come back in my chest wall and now keeps returning in lymph nodes. Last tim under my collar bone 3 years ago & I had cyberknife & put on Verzinio then Ibrance

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