Resveratrol, a substance manufactured from grapes, showed some effectiveness at reducing platelets, but research seems to have fizzled as interferon-based meds and JAK inhibitors like Jakafi were developed.

However, doctors don't prescribe HU alternatives often in the US because they are beyond the means of many patients. In 20 years, when the patents run out, they will be more affordable.

If you have ET and your platelets start showing a tendency to drop on their own (and especially if other counts are off) over the course of several months, that may be a sign of disease progression. Disease progression can make you feel crappy. So it's important to continue monitoring if you've decided to go off HU.

I sure wish that dark chocolate, red wine, watching "Fargo," knitting mittens, and reading PG Wodehouse would cure my ET! Sadly, there are no lifestyle "solutions" to a disease caused by a genetic mutation, though some of those things improve quality of life.

A heart-healthy diet and moderate exercise may reduce overall stroke risk. Avoiding food associated with inflammation may also help with symptoms. Still in the study phase last I heard.