I used the pellets years ago with seemingly no problems. I did have an elevated d dimer when tested for fainting but we don’t know what caused it. I started the cream about 2 months ago. 2 weeks ago I developed soreness in one breast and armpit. The PA doesn’t think the cream could cause this but I am not so sure. I am stopping use to see if it goes away. I suspect this internal use hormone has more side effects than they want us to believe. I’m sorry to hear this because I really wanted to ease my at atrophy, uti like cramps and dementia down the road. I may ask for the pellets again.