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No Parkinsons - possibly nOH (secondary-I am diabetic).
I would try doing 5mg with 3 hr spacing (check this idea out with Dr) if 10mg is raising BP that much. It takes about 45 min. for Midodrine to start to work-how soon after taking it does your BP go that high?
5mg to not raise so much but then again in 3 hrs to get sustained effect. Check BP & see how that does. I would NOT do 10mg every 3 hrs if your BP is going that high after taking 10mg
If I needed to go shopping/something on my feet all the time, I would take an extra 5mg about 1/2 hr before getting to the store. My BP was so low, my Dr actually had me taking 15mg 4x/day-added the 200mg Droxidopa when that wasn't working well enough (then I was able to cut back to 10mg with occasional 5mg "boost").
Right now I am off all the meds to raise my BP....don't know if it is the colder weather or what "re-set" me (might also be weight related-was in hospital & lost too much weight-just getting back to slightly over 100 pounds now). I was also able to go from 20-30mg compression socks to 15-20's. Was able to get off meds once before too when Dx'd w/Afib & had multiple ablations (No Afib episodes now since 2022).
Please let me know how you are doing. Don't forget to run this idea (5mg every 3 hrs instead of 10mg every 6 hr) by your Dr.
Replies to "No Parkinsons - possibly nOH (secondary-I am diabetic). I would try doing 5mg with 3 hr..."
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Lucy, I've worked up to 10mg 3xday....Anything lower has no effect. Besides, I'm 85 yo and the normal average BP would be closer to 140/90, not 120/80, unless you're 21 years old. I'm in constant contact via our Portal with my cardiologist and she has agreed with everything I'm doing, so far. I find that midodrine does not give me consistent results, however, better than nothing. It usually takes about 2 hours to work; sometimes longer! I take my BP with HR several times/day because I need to get my BP high enough to do my power walk (1 mile as fast as possible) and I can't do it with 106/65, or similar. I needs to be mid to high 130's or low 140's for me to feel good enough to walk....otherwise all I want to do is sleep! I know the recommended dosages and as I said, talk with my cardiologist, but I want to know exactly what others are doing and experiencing with their midodrine and not some inane advice from those who don't even take it or haven't experienced OH. Of course, this is not you! BTW my lowest BP was 68/46 on 4/29/2025.... It's no fun wasting 1/2 of your day before you feel like doing anything. I also want to know if anyone has experienced supine hypertension. I've fallen asleep many times after dosing with midodrine and it never affected my BP.