I took HU for 7 years. Never realized the side effects that were associated with that medication until I developed a sore on my ankle that neither my oncologist or my primary did anything for. Until I was in extreme pain and the sore was growing and spreading, then one of them said I needed to see a wound specialist. Finally the oncologist decided it was a side effect of the HU and changed my prescription to Jakafi. The best part of that change is that I don't itch all over all the time. Jakafi has been problematic for me because my hemoglobin dropped steadily to -8. Now I'm going to start Ojjaara next week. I need to stop reading the possible side effects of these medications, because Ojjaara scares me. Has anyone been taking Ojjaara for an extended time? What side effects have you experienced?