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@wesleym

Folks - you gotta read this stuff carefully. Taking the "studies" listed on this site in order by year:
2024: Sample size 1. Yes, 1.
2020: studied use of cucurmin in place of steroid (usually dex) to ameliorate effects of standard MM drug regimen in those already diagnosed.
2017: Sample size 6.
2017(2): sample size 13.
2017(3): same study as 2017(2).
2016: sample size 10 (MGUS cohort).
2015(1): sample size, CLL (chronic lymphocytic leukemia) patients 21; MGUS patients 0
2015(2): another CLL study; sample size 21
2015(3): sample size 1
2013: in vitro study.
2013(2): sample size 2
2012: the only double-blind placebo-controlled study of the group. Sample size: 36. Conclusion: "These findings suggest that curcumin might have the potential to slow the disease process in patients with MGUS and SMM." Note "suggest", "might" and "potential".
2011: Nothing to do with curcumin (or any other supplement).
2010: Vitamin D deficiency may increase damage MM does to bones. No kidding. Vitamin D is vital to bone health independent of MM.
2009: sample size 26.
All tiny, all equivocal, only one double-blind. I'm not suggesting that someone who - after consulting with physician - wants to take cucurmin should not do so. In the quantities discussed here, it is not likely to do any damage, other than potentially to iron absorption. I have high-risk MGUS / SMM, and know how you want to DO SOMETHING. But you have to read between the lines before getting your hopes up, especially on sites where - as here - they want to sell you stuff.

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Replies to "Folks - you gotta read this stuff carefully. Taking the "studies" listed on this site in..."

Good summary. I hadn't even noticed the link to all these papers. I based my opinion that Curcumin may not be helpful for IgM MGUS on just this one https://www.researchgate.net/publication/317419580_Long-term_follow-up_of_curcumin_treated_MGUSSMM_patients_-_an_updated_single_centre_experience
But am taking the C3 and iron supplements for now. I'm not getting my hopes up but I don't think the amount I'm taking has a down side. I'll know if it's worth continuing in a few months after the routine blood tests are done.