Brother: Extreme Psychosis & Suicidal w. + ANA NUCLEOLAR+More

Any opinions welcome for the case below. I feel his psychosis and delusions could be linked to an autoimmune issue creating neuro-inflammation. I would love to know if anyone has had similar results with a similar diagnosis or give any support or directive advice. Thank you so much and God Bless.
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Clinical Summary: Case Overview of Persistent Neuroimmune Symptoms in a 22-Year-Old Male

This document outlines the key lab and imaging findings for a 22-year-old male patient presenting with persistent neuropsychiatric symptoms following suspected infectious triggers.

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Infectious Serology:
• Epstein-Barr Virus (EBV):
• VCA IgG: 7.7 AI (Reference: < 0.9)
• EBNA IgG: >8.0 AI (Reference: < 0.9)
• VCA IgM: < 0.2 AI (Reference: < 0.9)
• Streptococcus (ASO Titer):
• ASO: 285 IU/mL (Reference: < 200 IU/mL)

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Autoimmune Testing:
• Antinuclear Antibody (ANA):
• Result: Positive
• Titer: 1:160
• Pattern: Nucleolar

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Neuroimaging:
• MRI Brain (T2 FLAIR):
• Focal hyperintensity in the left corona radiata nonspecific
• No additional white matter abnormalities noted
Impression:
No acute abnormality is appreciated.

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Cerebrospinal Fluid (CSF) Studies:
• Oligoclonal Bands: 0 (CSF and serum matched)
• Autoimmune Encephalopathy Panel (Mayo Clinic, CSF):
• All tested antibodies negative, including:
• NMDA-R, AMPA-R, GABA-B
• LGI1, CASPR2, DPPX, GAD65
• ANNA-1, ANNA-2, CRMP-5, PCA-1, PCA-2
• GFAP, TRIM46, Septin-7

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Pending or Not Yet Tested:
• Myelin Basic Protein (CSF): In progress

This case is being shared in the interest of gathering medical insight from the broader neuroimmunology and autoimmune neurology communities. Any clinical patterns or considerations based on these findings would be welcomed.