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Anyone familiar with the clinical trial RMC-6236? Or how to enroll?
Pancreatic Cancer | Last Active: Jun 24 12:39pm | Replies (58)Comment receiving replies
@mnewland99 , I think the trial you're referring to is https://www.clinicaltrials.gov/study/NCT06625320, described on the COH search page for Protocol No. 24607 as:
"Title: RASolute 302: A Phase 3 Multicenter, Open-label, Randomized Study of RMC-6236 versus Investigator's Choice of Standard of Care Therapy in Patients with Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)"
I'm not willing to take the chance of being randomized.
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@gamaryanne , It was actually Dr. Kim who told me I didn't qualify for his trial. He's got me on the waiting list for another possible KRAS trial (different drug, different manufacturer) in 3-4 months.
My MRI showed notable progression since March, and my CA19-9 has gone from low 60's in March to 700 this week, so I'm scrambling , counting frequent-flier miles, and casting the nets a bit farther out, hoping to find something before Dr. Kim comes through.
My only known actionable targets remain the ATM and KRAS G12D mutations, and the expression of TROP2 (for which the last trial failed). I could possibly get a PARP inhibitor to nibble away at ATM, but my primary oncologist is pretty skeptical about its value.
Thanks again to both of you for the leads.
Replies to "@mnewland99 , I think the trial you're referring to is https://www.clinicaltrials.gov/study/NCT06625320, described on the COH search..."
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I get about not being a fan of randomized. I also chose not to take that path. Have you had any recent scans to find any new growths? This time pain on my right side was an indicator before my CA19-9 started rising sharply. As you well know, you have to know where new growth is, if any, to know your most effective line of treatment. CT was done, but drs couldn’t tell what was inflammation from my past radiation or what was new, so they ordered PET and laid the 2 images on top of each other to get a result. I asked another dr for MRI; so we had all three and just prior I got angiogram CT of my lungs as a follow up on a benign nodule I had.
New growth in liver again, though they said they cant Gus one it’s not anywhere else based on my high CA19-9 they said. I wish they would do ERCP, but they don’t think it’s necessary. I’ve decided to the Naliri. Have you researched it yet? I hope it’s an option for you. I’m very curious what you said about PARP to “nibble” away at the ATM - that is new information for me. As always, my friend, God’s guidance in decision making of your next step.