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Anyone familiar with the clinical trial RMC-6236? Or how to enroll?
Pancreatic Cancer | Last Active: May 24 7:16am | Replies (34)Comment receiving replies
@mnewland99 , Thanks for the info. Do you have the NCT trial # for the one at COH?
The only ones I'm aware of w/ RMC-6236 are either Phase 3 (randomized; not going there) or in combination w/ other SoC chemo drugs that I haven't already had.
Even though 6236 is an oral med I could take at home, I don't think I could get into a trial at COH without frequent travel back to CA since they want to measure absorption rates and blood concentrations -- I doubt I could find a local lab/provider willing, capable, or approved to do the tests that study requires.
The only SoC drug I haven't tried is Onivyde (the new nano-liposomal irinotecan). I asked my onc today if I should switch to that as a bridge until I qualify for a trial. I was advised not to, because the likely failure/progression on another line of therapy would jeopardize my chances of getting into a trial with more promise.
I'll be getting tested for expression of CLDN18.2 soon, and checking into other studies. There are some KRAS G12D trials with drugs other than RevMed's.
Replies to "@mnewland99 , Thanks for the info. Do you have the NCT trial # for the one..."
24607 - it’s a phase 3. The researcher has choice of chemo drugs (from a list):
Drug: Gemcitabine
Drug: nab-paclitaxel
Drug: Irinotecan
Drug: Liposomal irinotecan
Drug: 5-fluorouracil
Drug: leucovorin
Drug: Oxaliplatin
From clinical notes of my visit, I read that liposomal irinotecan and maybe they could mix in the 5-FU was going to be the alternative, if I did t get the target drug. This is Naliri. This wasn’t conveyed to me at the time. However, I still would rather go with SBRT for my new liver lesion or histotripsy or vice versa (after what I find out next week from dr about histotripsy), and then after those are completed and should I have further metastasis, then I would go on the RMC-6236. That’s just my plan. My dr doesn’t mention a word about the vaccine he touted during my original consultation with him so I don’t know what’s up with that. You might try to reach Dr. Kasi to see what he thinks since he said (when I mentioned your case) that it might be difficult, but it wasn’t a firm “no”. I’m suppose to start Naliri on Tuesday, so I’ll let you know how it goes.
That’s the protocol number I gave you. I found it by searching (safari) for city of Hope clinical trials, then just putting in “pancreas” for disease on their search box once you’ve accessed their clinical trials page. Let me know if you haven’t found it.
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@markymarkfl
Have you tried Moffett? I understand Dr Kim is quite knowledgeable of trials and may be running some. He has become a second opinion “go to” for some in atlanta.