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Can anyone share their experience with Pluvicto?

Prostate Cancer | Last Active: Sep 25 5:56pm | Replies (241)

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Profile picture for jeff Marchi @jeffmarc

Be aware that 1/3 of people have really good results from Pluvicto, 1/3 Respond OK and 1/3 get nothing from it.

Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto

Have you had a hereditary Test or a somatic test? It would be good to have both before having Pluvicto So you can see if you have a genetic conflict.

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

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Replies to "Be aware that 1/3 of people have really good results from Pluvicto, 1/3 Respond OK and..."

Hi Jeff
I think that I am one of the lucky ones in the top 1/3.
I just completed infusion # 3 with minimal side effects,
My PSA has dropped like a rock, started at 78 dropped to 39 then to 12.
I am going to talk to my oncologist about pausing treatments 4,5, & 6 . Save some ammunition for went
the PSA goes back to 80.
The Best of Luck
Willis Beavers

Has anyone heard information on whether the radiation of Pluvicto targets and damages healthy tissue as well the cancerous tissue? Asking because salvage radiation damaged my bladder and destroyed the urethra. Want to avoid a reoccurrence.

@jeffmarc
What if you have PTen and TP53 as well as ATM and BRCA?