Weaning off Effexor- is there any way to make this more bearable?

Posted by lilred @lilred, Nov 26, 2018

Okay, hi. I’ve been on 300mg of Effexor XR for around three or four years. It stopped helping me once I started getting older (I was put on it when I was just about past age eighteen) and my doc and I made a mutual decision to wean off but only after starting Wellbutrin and making sure it helped me first. Decreased by 37.5mg every three days, and felt fine besides a bout of irritability here and there. As soon as I was finished weaning off I started having terrible side effects. I felt like I was going to pass out one day, have barely had an appetite, and for the past two days have had awful brain zaps. I’m also extremely anxious and am constantly worrying if these side effects are normal and if they will ever go away.
Does anyone know of any way to get at least the brain zaps (they’re my biggest complaint tbh) under control a bit more?

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@judyham

I would like to know about this too.

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Hi, @judyham, and welcome to Mayo Clinic Connect. I wanted to suggest you click on VIEW & REPLY in your email notification, so that way you will see the whole discussion and can join in, meet, and participate with other members talking about their or their loved ones' experiences.

What kinds of questions or concerns do you have about weaning off of venlafaxine (Effexor)?

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I have just weaned my self from Pristique it is several weeks now. I was on 50 Micrograms a day and I started week 1. M50:T25:W50:Th25:F50:S25:Sun50.
OI did this by cutting the tablet on my doctors advice as there is no smaller dose. The following week I increased the 1/2 tablets to 4 days the 3rd week all 1/2 tablets then 5th wee 3 days n tablet 6th week 4 days no tablet 7th wee no tablets. My doctor gave me panadol fort for the migraines and stemetil for the nausea. I only took as needed I had 2 scripts for stemetil but only used a few panadol forte. Mainly at night so I could sleep. When I was completely off I developed flu like symptoms with sever neck shoulder and head pain she gave me 1 script for valium and that fixed it one tablet one night . I still get some zapping at night but all the other symptoms are gone except the ones like poor memory, I had increased bladder weakness and memory but its all settling now and I feel so much better. Thanks

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I found that stemetil for the nausea was good and the peppermint Migrastick really helped with headaches but when it got too bad I used panadol forte. My doctor is great and trusts my judgement she gave me valium for the pain and stiffness I got in neck and shoulders abd I took one at night once and it fixed it. Asa I was bef
ginning to feel better Peppermint worked instead of stemetil

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@joannapickford7

I have just weaned my self from Pristique it is several weeks now. I was on 50 Micrograms a day and I started week 1. M50:T25:W50:Th25:F50:S25:Sun50.
OI did this by cutting the tablet on my doctors advice as there is no smaller dose. The following week I increased the 1/2 tablets to 4 days the 3rd week all 1/2 tablets then 5th wee 3 days n tablet 6th week 4 days no tablet 7th wee no tablets. My doctor gave me panadol fort for the migraines and stemetil for the nausea. I only took as needed I had 2 scripts for stemetil but only used a few panadol forte. Mainly at night so I could sleep. When I was completely off I developed flu like symptoms with sever neck shoulder and head pain she gave me 1 script for valium and that fixed it one tablet one night . I still get some zapping at night but all the other symptoms are gone except the ones like poor memory, I had increased bladder weakness and memory but its all settling now and I feel so much better. Thanks

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Hi, @joannapickford7 - Welcome to Mayo Clinic Connect. Sounds like your doctor was with you all the way on your taper off of desvenlafaxine (Pristiq).

One thread you may want to look at and potentially post in is "Want to Taper Off Pristiq - Makes My Heart Race," which started in 2012 and is still going as a discussion now in 2018. I think other members there would be interested in your experiences and how your doctor had you navigate some of the side effects of the taper.

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I'm now to ths not sure what a thread is tho I can guess and dont know how to find it I wanted to write my experience with a doctors help so others can see it can be done. I still have some residual zapping and those memory things that these drugs protect so bladder weakness again and memory really bad but hoping they will come good with time I was on Pristique for situational depression for & years tried so many time to come off. It's a horrid drug.I mean it helped initially but you should be able to come off drugs you no longer need. I was upset that if I forgot a pill I would be sick with Migrane and Nausea for a day till the next one kicked in!

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@joannapickford7

I'm now to ths not sure what a thread is tho I can guess and dont know how to find it I wanted to write my experience with a doctors help so others can see it can be done. I still have some residual zapping and those memory things that these drugs protect so bladder weakness again and memory really bad but hoping they will come good with time I was on Pristique for situational depression for & years tried so many time to come off. It's a horrid drug.I mean it helped initially but you should be able to come off drugs you no longer need. I was upset that if I forgot a pill I would be sick with Migrane and Nausea for a day till the next one kicked in!

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Hi, @joannapickford7 - a thread is a discussion here on Connect (or another online community). Sounds like you'd guessed exactly that. My apologies that I neglected to post the link to the "Want to Taper Off Pristiq – Makes My Heart Race" discussion. It's https://connect.mayoclinic.org/discussion/pristiq-withdrawal. Hoping you will share some of what you've gone through with the members there.

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@grandmar

@lilred
Hello!
There are many of us trying to come off of Effexor, who are experiencing the same thing you are.
I just started last week weaning down from 150mg in the am and pm.
I have not yet experienced the 'zaps.'

Mayo Clinic has excellent newsletters you can sign up for for.
Today I got one I think might interest you and others......

ANTIDEPRESSANT WITHDRAWAL: IS THERE SUCH A THING?

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If you stop taking antidepressants, could you experience antidepressant withdrawal? Do withdrawal symptoms mean you were addicted to the drug?
Answer From Daniel K. Hall-Flavin, M.D.
Antidepressant withdrawal is possible if you abruptly stop taking an antidepressant, particularly if you've been taking it longer than six weeks. Symptoms of antidepressant withdrawal are sometimes called antidepressant discontinuation syndrome and typically last for a few weeks. Certain antidepressants are more likely to cause withdrawal symptoms than others.

Quitting an antidepressant suddenly may cause symptoms within a day or two, such as:

Anxiety
Insomnia or vivid dreams
Headaches
Dizziness
Tiredness
Irritability
Flu-like symptoms, including achy muscles and chills
Nausea
Electric shock sensations
Return of depression symptoms
Having antidepressant withdrawal symptoms doesn't mean you're addicted to an antidepressant. Addiction represents harmful, long-term chemical changes in the brain. It's characterized by intense cravings, the inability to control your use of a substance and negative consequences from that substance use. Antidepressants don't cause these issues.

To minimize the risk of antidepressant withdrawal, talk with your doctor before you stop taking an antidepressant. Your doctor may recommend that you gradually reduce the dose of your antidepressant for several weeks or more to allow your body to adapt to the absence of the medication.

In some cases, your doctor may prescribe another antidepressant or another type of medication on a short-term basis to help ease symptoms as your body adjusts. If you're switching from one type of antidepressant to another, your doctor may have you start taking the new one before you completely stop taking the original medication.

It's sometimes difficult to tell the difference between withdrawal symptoms and returning depression symptoms after you stop taking an antidepressant. Keep your doctor informed of your signs and symptoms. If your depression symptoms return, your doctor may recommend that you start taking an antidepressant again or that you get other treatment
Products and services
Mayo Clinic on Better Hearing Balance
Free E-newsletter
Subscribe to Housecall

Our general interest e-newsletter keeps you up to date on a wide variety of health topics.

Sign up now
If you stop taking antidepressants, could you experience antidepressant withdrawal? Do withdrawal symptoms mean you were addicted to the drug?
Answer From Daniel K. Hall-Flavin, M.D.
Antidepressant withdrawal is possible if you abruptly stop taking an antidepressant, particularly if you've been taking it longer than six weeks. Symptoms of antidepressant withdrawal are sometimes called antidepressant discontinuation syndrome and typically last for a few weeks. Certain antidepressants are more likely to cause withdrawal symptoms than others.

Quitting an antidepressant suddenly may cause symptoms within a day or two, such as:

Anxiety
Insomnia or vivid dreams
Headaches
Dizziness
Tiredness
Irritability
Flu-like symptoms, including achy muscles and chills
Nausea
Electric shock sensations
Return of depression symptoms
Having antidepressant withdrawal symptoms doesn't mean you're addicted to an antidepressant. Addiction represents harmful, long-term chemical changes in the brain. It's characterized by intense cravings, the inability to control your use of a substance and negative consequences from that substance use. Antidepressants don't cause these issues.

To minimize the risk of antidepressant withdrawal, talk with your doctor before you stop taking an antidepressant. Your doctor may recommend that you gradually reduce the dose of your antidepressant for several weeks or more to allow your body to adapt to the absence of the medication.

In some cases, your doctor may prescribe another antidepressant or another type of medication on a short-term basis to help ease symptoms as your body adjusts. If you're switching from one type of antidepressant to another, your doctor may have you start taking the new one before you completely stop taking the original medication.

It's sometimes difficult to tell the difference between withdrawal symptoms and returning depression symptoms after you stop taking an antidepressant. Keep your doctor informed of your signs and symptoms. If your depression symptoms return, your doctor may recommend that you start taking an antidepressant again or that you get other treatment

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If I miss a dose of Effexor, I have blurred vision, involuntary muscle contractions (spasms) of the eyes, complete numbness of my tongue and parts of my face, and cannot stop crying and feeling terrified.

The withdrawals from this drug are not merely bothersome. They can be downright DANGEROUS.

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@hmoc

If I miss a dose of Effexor, I have blurred vision, involuntary muscle contractions (spasms) of the eyes, complete numbness of my tongue and parts of my face, and cannot stop crying and feeling terrified.

The withdrawals from this drug are not merely bothersome. They can be downright DANGEROUS.

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Hi all...
You are all correct that trying to come off Effexor, or trying to reduce your dosage can be DANGEROUS if you do it too quickly. For some reason, the paperwork does not tell you this.
At an extremely difficult time in my life, my dosage was almost doubled. When things were better, I wanted to reduce my dosage. My then doctor said to reduce it every other day. From my research, I knew this would be far too quick.
I came up with my own method to reduce, which I will share. This WILL take quite a bit of time to do. I had absolutely NO SIDE EFFECTS from this method. PLEASE KNOW THAT I AM IN NO WAY A MEDICAL PERSON!!!!!
I was taking a pill in the morning and a pill at night.
I got an AM/PM pill case ans a pill cutter. If you are taking a capsule, it is more difficult.
I worked on reducing the AM dosage first. I did exactly the same thing for the PM dosage.
1. I cut all my PM pills into quarters.
2. I put 3 quarters of a whole pill in the box. I took this dosage for one week. If I had no reaction, I continued for another week. I did this for a total on 4 weeks. IF there were any reactions, I stayed on the dosage another week.
3. After 4 weeks in a row with NO reaction, I went to half a pill for 4 weeks. If there was a reaction, you go back up to the previous dosage for a week. If all is good, then go back down. Remember, the goal is 4 weeks in a row of the new dosage with NO side effects.
5. Continue this process, removing one additional quarter at a time, until you get to where you want to be.
6. If you have an AM dosage that you want to reduce, too, be on your new PM dosage for 1 month before trying to reduce your AM. Then, use the same procedure.
As I said, this takes a while and you probably won't have any side effects.
Again, I AM NOT A MEDICAL PERSON. I DEVELOPED THIS ON MY OWN BASED ON MY OWN READINGS.
GOOD LUCK!
If you have any questions I am more than happy to help.

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I weaned off them about 10 years ago. It was a horrible experience! The worst part for me was anxiety. I remember waking up in the middle of the night panicking so bad that it scared me! This happened for about a month. The brain zaps were pretty bad too. I can tell you that it will all pass, completely! It will all just stop, I can’t say when but if it’s tolerable, bear with it. Good luck

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