Welcome to the group! I am 65 yr old female. Have had MAC at least 3 times. Now have MAC and Aspergillosis together. I have taken the big 3 daily. Keep in mind that everyone responds differently to medication. My worst side effects were nausea and fatigue. To reduce side affects pull. dr changed my RX schedule to 3 days a week of the big 3. Dr gave me Zofran RX for nausea. I was on this regimen for 18 months and 2 yrs. Doctors can adjust meds. Have never done airway clearance until this time around. The best isn’t working for me. Nebulizer with 7 % saline helps. I have been told MAC is slow growing also. But I have other lung problems and doctors recommend to treat. I hope you get helpful information from everyone’s posts on here. Please keep us updated. Best of luck to you. Praying for you.