I had my first Reclast infusion 3 days ago and, other than some mild flu-like symptoms the day after the infusion, I've had no other side effects and feel totally normal today. I was terrified to have the infusion after reading some of the horror stories on these boards, but knew I needed to do something to "lock in" the gains I had made with Tymlos so I went with my doctor's recommendations. I knew there was a "chance" I'd be in the very small minority that has a bad reaction (I tend to be very sensitive to medications and don't even like to take aspirin), but went for it anyways and am glad that I did as I knew doing nothing wasn't an option. I will have another infusion in one year and a third the following year, then take several years off all drugs with bone marker testing after 3 years to keep an eye on when it's time to start something else. My doc did do several tests before recommending Reclast (to ensure kidney's, calcium and d levels were still good). I did request a slow infusion over an hour, which the infusion nurse accommodated (they did do a saline flush at the end as well). I was VERY well hydrated and continue to keep well hydrated afterwards (so much water!) and took Tylenol just before they started the infusion, that night and several times the next day.