Persistent elevation of absolute immature granulocytes 7 months 0.04

Posted by lightgoddess @lightgoddess, 1 day ago

Blood (CBC-Diff) test at ER in October 2024 and again in May 2025 show 0.04 elevation in absolute immature granulocytes. Lab note says: "Immature granulocytes are left-shifted granulocytes and do not equal blasts. They are composed of metamyelocytes, myelocytes, and promyelocytes. Their presence can be seen in infection, inflammation, certain medication effects, or other bone marrow stimuli. Occasionally, persistent increase in immature granulocytes may be part of myeloid neoplastic process. Correlation with clinical findings is recommended for complete interpretation of this parameter. Please also note that peripheral blood with immature granulocytes >5% will be manually reviewed by lab personnel and/or pathologists." My Dr is dismissing this persistent elevation and says it is of no concerns without any further diagnostics....just wants to ignore it. What should I do?

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Lab work (CBC-Diff) in oct 2024 and again in May 2025 shows 0.04 elevation in Absolute immature granulocytes. Notes from Lab say "Immature granulocytes are left-shifted granulocytes and do not equal blasts. They are composed of metamyelocytes, myelocytes, and promyelocytes. Their presence can be seen in infection, inflammation, certain medication effects, or other bone marrow stimuli. Occasionally, persistent increase in immature granulocytes may be part of myeloid neoplastic process. Correlation with clinical findings is recommended for complete interpretation of this parameter. Please also note that peripheral blood with immature granulocytes >5% will be manually reviewed by lab personnel and/or pathologists." My Dr says no concerns and dismissed both lab reports and is disinterested in investigating underlying cause. I know it isn't a really high level but have been having some strange symptoms we thought may be cardiac but other symptoms that concern me. Mostly concerned that is has persisted 7 months. Not just worried about worst case scenarios but also at whether we should be looking into possible infection or inflammatory response at the very least. Doesn't seem a good thing to ignore possible persistent infection or inflammation either....is it?

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@lightgoddess

Lab work (CBC-Diff) in oct 2024 and again in May 2025 shows 0.04 elevation in Absolute immature granulocytes. Notes from Lab say "Immature granulocytes are left-shifted granulocytes and do not equal blasts. They are composed of metamyelocytes, myelocytes, and promyelocytes. Their presence can be seen in infection, inflammation, certain medication effects, or other bone marrow stimuli. Occasionally, persistent increase in immature granulocytes may be part of myeloid neoplastic process. Correlation with clinical findings is recommended for complete interpretation of this parameter. Please also note that peripheral blood with immature granulocytes >5% will be manually reviewed by lab personnel and/or pathologists." My Dr says no concerns and dismissed both lab reports and is disinterested in investigating underlying cause. I know it isn't a really high level but have been having some strange symptoms we thought may be cardiac but other symptoms that concern me. Mostly concerned that is has persisted 7 months. Not just worried about worst case scenarios but also at whether we should be looking into possible infection or inflammatory response at the very least. Doesn't seem a good thing to ignore possible persistent infection or inflammation either....is it?

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Hi @lightgoddess It’s understandable to be concerned when you’re feeling ‘something isn’t quite right’ and having your doctor be dismissive.
If this were me, I’d be seeking a second opinion. Have you been seen by a hematologist?

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@loribmt

Hi @lightgoddess It’s understandable to be concerned when you’re feeling ‘something isn’t quite right’ and having your doctor be dismissive.
If this were me, I’d be seeking a second opinion. Have you been seen by a hematologist?

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Not yet....wasn't sure if I needed one. Appointment next month and I will discuss that with PAC (since Dr is on 10 week vacay) and will ask about it. Of course they will want me to wait a few to several months before they will actually give me a referral. Only ever asked for 2 referrals from them. One for Physical Therapy per surgeon's instructions (they told me that would take 6 months). Cardiac symptoms also since February along with BP and HR readings all over the place and told at LEAST 3 months to see Cardiologist. I wonder if I can get into seeing a Hematologist w/o primary care referral? Not really confident in my UHC provider network atm and not sure where to go from here. I don't want to over react but this has been an issue since last October and if an issue AND persistent as well then I don't know if I should just sit back and ignore this. I only found the results by accident. No one said a word to me about it though both tests are in their records for me.

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