One thing is for sure, medial layer calcification is not well understood. I have seen three cardiologist about my high CAC score, and you would be surprised at how different their treatment recommendations were. One wanted to do the test again in two years, but another said to never take the test again. One wanted me on 20MG of Lipitor, the other two wanted me on 80 (I switch to 80). I am seeing a lipid specialist now, and will see him every six months. He said that I was an outlier at 54 years old with a CAC score of over 2700. Alot of people recommend to trust your doctor, but it's difficult to do that when I know they don't really know what my condition means or how it will manifest itself later. The best advice so far is to somehow just keep living, and be not be so worried about something I seemingly can't control. I am not an avid exerciser, but I try and walk as often as I can. I also lost alot of weight, and my blood pressure has been way better than it was. So.. I guess I press on.