I don’t know if there’s any relativity here, but I left my Tymlos pens out after the first use - my home stays a constant temp year ‘round. However, while on Evenity, my nurses told me that taking the syringes out of the fridge for about half an hour prior to the injection would make them more tolerable. Although I had no adverse reactions to speak of, that one little thing did seem to help.

Cheers!!