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Anyone seen research on long term Proton Pump Inhibitor use and PN?

Posted by blearyeyes @blearyeyes, Aug 16, 2023

Anyone seen research on long term OTC Proton Pump Inhibitor use and PN?

I just read an article (on the internet) about anecdotal evidence of long term use of over the counter PPI use as a cause of Neuropathy along with a bunch of other issues.

I was told I would have to take PPIs for life for GERD by an Gastroenterologist 15+ years ago. Now they are saying don’t take more than 2 x 14 day runs a year.

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deserthykr | @deserthykr | 1 day ago
In reply to @bigjohnscho "I have a very unreceptive GP who doesn’t respond well to questions. He seems to regard..." + (show)
@bigjohnscho

I have a very unreceptive GP who doesn’t respond well to questions. He seems to regard them as challenging his authority

John

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Can you find another doctor for yourself?

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lindavs | @lindavs | 1 day ago
In reply to @bigjohnscho "I have a very unreceptive GP who doesn’t respond well to questions. He seems to regard..." + (show)
@bigjohnscho

I have a very unreceptive GP who doesn’t respond well to questions. He seems to regard them as challenging his authority

John

Jump to this post

Please consider changing doctors. I had been on medical literature for many years that PPI,'s should only be used on a temporary short term basis. BTW, have you ever been tested for celiac disease. Requires an endoscopy and blood tests, which should include (if you have a really good gastroenterologist.) I was told for years that I had GERD and was put on a PPI for a number of years. He retired and I got a much younger gastroenterologist. He immediately started weaning me off PPI and scheduled me for an endoscopy. Turns out I had celiac disease. Do some research on celiac on this site. You may indeed have something other than celiac but it is often misdiagnosed in adults.
By the way, I have PN in both feet and legs, to just above the knees. There is a link between celiac and neuropathy as well. Mayo main website also has lots of info on issues re: PPIs.

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lindavs | @lindavs | 1 day ago

This is an article written for medical professionals but much of it is understandable. Worth a persistent read.
https://www.mayoclinicproceedings.org/article/S0025-6196(17)30841-8/fulltext

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bigjohnscho | @bigjohnscho | 19 hours ago
In reply to @johnbishop "Have you been tested for vitamin B12 deficiency? You might want to check with your doctor..." + (show)
@johnbishop

Have you been tested for vitamin B12 deficiency? You might want to check with your doctor to see if the long term PPI usage is affecting your B12 level.

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John, I would like to start taking RALA but when I tried it before, although I felt some benefit it upset my stomach. Is there any way I can solve that problem. I was only taking 200mg

John

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John, Volunteer Mentor | @johnbishop | 16 hours ago
In reply to @bigjohnscho "John, I would like to start taking RALA but when I tried it before, although I..." + (show)
@bigjohnscho

John, I would like to start taking RALA but when I tried it before, although I felt some benefit it upset my stomach. Is there any way I can solve that problem. I was only taking 200mg

John

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Quite a few folks have stomach issues if they start with a high dose of R-ALA. Most have had success by starting with 100 mg capsule daily and then after a week or so increasing to a larger dose until they get to their normal dose which for me is 600mg morning and evening for 1200 mg daily. Another thing to try is to eat something when you take it like part of a banana.

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