Has anyone ever been on Duloxetine (Cymbalta) for nerve pain?

Posted by dougs72 @dougs72, Jun 22, 2024

Has anyone ever been on Duloxetine (Cymbalta) for nerve pain? I've had 2 doctors push this on me. I know that the side effects can be terrible and getting off of it difficult as it requires titration. One time I remember taking one pill, and not liking the way it made me feel, so not taking any more, and still feeling the "weirdness" from it 2-3 days later. and that was only 30 mg Please pass along any experience or advice from this medication?

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@bunstuffer

The ONLY thing that ramps my pain down is hydrocodone. I have tried everything including cannabis. My husband as been taking hydrocodone for at least 15 years for spinal stenosis because they couldn't operate due to his heart condition. I only take hydrocodone or half once a day at most and try to get by as much relief as possible with Advil Dual or Aleve. Some of my friends about have a spell if I tell them I take it. My doc feels that if you have exhausted the alternatives and use it responsibly and as prescribed ,it's fine.
Yes, depression goes with pain. The duloxetine did help with that to begin with. It put me in the hospital twice and I couldn't eat for 2 weeks when I went off of it. I don't want anything more to do with SSRIs/SNRIs

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You are very helpful. I think I will stick to my plan to not increase the duloxitine and if quits working, I will have to find another solution.

I don’t care what it takes. Living with pain isn’t living.

Thanks again and God bless!

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Ever since I turned 50 and I had thyroid problems and ultimately wound up on Lyrica. I have no idea where all my weight gain is come from but I'm not sure if I can disregard that I will gain weight from Lyrica. It's been too many years for me to really remember. Good luck though

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My primary prescribed Cymbalta last year for fibromyalgia, severe OA (hands, feet, rib cage and neck) Occipital neuralgia and depression. He told me that my pain would go away. And that fibromyalgia would go away, and I would be happy again.

I procrastinated for months, but finally took it and I was so sick every single day for over a week. You name the symptom, I had it.
I am such a lightweight when it comes to taking any medications.
For the burning pain and the occipital neuralgia, the only thing that helps is low dose diclofenac.
But I’ve always been apprehensive to take
it because of my age and of course I ended up with kidney disease stage 2 from taking it every day.
For me, it was a wonder drug that gave me my life back.
But again, I can only take it two times a week so I look forward to those two days so that I can get out with my husband or take a walk or do a little housework. My back up medication is low dose Vicodin, once a day which is barely helping.
My heart goes out to all of you dealing with this pain.
Sending comforting hugs to you all.

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My rheumatologist put me only Cymbalta for Reactive Arthritis and I was in acute pain - I would have taken anything. That was 10 years ago and I’ve tried to taper off of it over and over. It’s extremely hard to get off of. Withdrawal symptoms are awful. Do not start it!!!!

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@liannybird

My rheumatologist put me only Cymbalta for Reactive Arthritis and I was in acute pain - I would have taken anything. That was 10 years ago and I’ve tried to taper off of it over and over. It’s extremely hard to get off of. Withdrawal symptoms are awful. Do not start it!!!!

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You can't say that for everyone.
I cold turkeyed once. I felt a little weird for a few days . I am now back on 60mg a day. Better than the pain.!

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@liannybird

My rheumatologist put me only Cymbalta for Reactive Arthritis and I was in acute pain - I would have taken anything. That was 10 years ago and I’ve tried to taper off of it over and over. It’s extremely hard to get off of. Withdrawal symptoms are awful. Do not start it!!!!

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You said , "Do not start it..." But we need to remember that every single person is different, and reacts differently to medication/surgery/therapy/supplements. I am like @ams - duloxetine gave me back my life after being a virtual couch potato, just hunkered down and miserable. My dose varies from 60 - 150 MG per day, depending on my symptoms, and I have never had an issue either reducing or increasing the dose.
So, as a fellow Connect member,
I might tell others "be cautious, I had [describe unpleasant reaction] to that medication/treatment. But the other person must feel free to consider my opinion but make their own decisions.
What do you use in place of duloxetine?

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I just went back on Cymbalta after trying it years ago. I am desperate to find something to help the pain, so thought I would try again. Have been on it 4 weeks now and haven’t seen significant change in pain, yet. However doctor said it doesn’t work for 4-6 weeks and then the dosage will need to be increased. We will see. I am hopeful.

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@sueinmn

You said , "Do not start it..." But we need to remember that every single person is different, and reacts differently to medication/surgery/therapy/supplements. I am like @ams - duloxetine gave me back my life after being a virtual couch potato, just hunkered down and miserable. My dose varies from 60 - 150 MG per day, depending on my symptoms, and I have never had an issue either reducing or increasing the dose.
So, as a fellow Connect member,
I might tell others "be cautious, I had [describe unpleasant reaction] to that medication/treatment. But the other person must feel free to consider my opinion but make their own decisions.
What do you use in place of duloxetine?

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I stand by my warning.

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Yes and it is helpful for me at low doses. Depends on the individual and the condition, but if a neurologist prescribes it, it’s worth a try.

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I take 30mg of Cymbalta and 1200mg of Gabapentin at night and the combination seems to help most nights with the foot and leg pain from my diabetic neuropathy. I’m one of the lucky ones who never seems to have any side effects from medications.

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