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Targetable Mutations
Please list the mutations which currently have treatments that are targettable.
I think we all know that KRAS G12D is one in which several trials are in place.
And for people who are MSI High, Keytruda is a possibility.
Are there others?
Thank you for any updates!
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I have ann ipmn with kras mutation. No worrisome features. Dr said 6 month followup.
I asked about kras inhibitors as prevention. I think he said its not done and there are serious side effects.
I feel like a time bomb waiting to go off.
Anyone else with this and with suggedtions?
Thank you.
If you have peritoneal cancer, there is a protein Claudin 18.2 that may accompany it. It’s not a mutation, “it's not a direct result of a change in the DNA sequence (a mutation) but rather a change in how the gene is processed to produce the protein”. You must have at least a 75% occurrence of it (abdominal, ovarian areas) in order to be able to receive drug which was after trials last couple of years, approved by FDA in December 2024; drug is Zolbetuximab (Vyloy). I had my biopsy tissue tested and I have an 80% occurrence of it. I would like to know if it’s associated with a known mutation like TP53 or ATM. It can occur with adenocarcinoma is all I know. I have ATM VUS (variant of unknown significance) and TP53. I was told by my first Dr (but you don’t have the ATM mutation). I disagreed in that it’s a base substitute that science just doesn’t have enough research on, yet. My father had pancreatic cancer and his mom had breast cancer, certainly there’s a link and my guess is ATM. The gastric cancer was the one that was so insidious at the end.