CAR-T after MM relapse 13 months post-ASCT

Posted by jrbris23 @jrbris23, 1 day ago

Hi everyone, looking for some advice on pursuing CAR T after a fairly quick (13 month) relapse of multiple myeloma light chains numbers trending up post stem cell transplant. I’m feeling strong and back to a near-normal life so frustrating to feel like I’m starting another arduous process. Would love any success stories on CAR T in this type of relapse situation or any alternative paths people have succeeded with. Thank you so much!

Interested in more discussions like this? Go to the Bone Marrow Transplant (BMT) & CAR-T Cell Therapy Support Group.

Colleen Young, Connect Director | @colleenyoung | 1 day ago

@jrbris23, welcome. There are several members I can connect you with who have talked about CAR-T therapy for multiple myeloma like @4health4bonnie @cjj2 @pgollinger @myelomawarrior.

While we wait for them to jump into the discussion, you might be interested in reading this related discussion:
- Starting pre-tests for CAR-T infusion for multiple myeloma https://connect.mayoclinic.org/discussion/car-t-infusion-for-multiple-myeloma/

Jrbris23, I can imagine how frustrating it must be to consider embarking on another arduous journey after already having had a stem cell transplant just over a year ago. Thank goodness CAR-T therapy is now a viable option.

Are you scheduled to start CAR-T or is this something you're still considering?

dandgk721 | @dandgk721 | 1 day ago

Ask about bispecific antibodies therapy. It is approved for multiple myeloma patients...studies show good results...

jrbris23 | @jrbris23 | 1 day ago

In reply to @colleenyoung "@jrbris23, welcome. There are several members I can connect you with who have talked about CAR-T..." + (show)

Thank you Colleen. It is for my mom who underwent ASCT last March and as of a month ago light chains were trending back up. We have had the first conversation with oncology and transplant surgeon about CAR-T but have a second opinion appt scheduled in two weeks to gather more information. CAR T seems to be the suggested next step but I’m trying to get educated to help advocate for her

jrbris23 | @jrbris23 | 1 day ago

In reply to @dandgk721 "Ask about bispecific antibodies therapy. It is approved for multiple myeloma patients...studies show good results..." + (show)

Thank you, I will!

Colleen Young, Connect Director | @colleenyoung | 1 day ago

In reply to @jrbris23 "Thank you Colleen. It is for my mom who underwent ASCT last March and as of..." + (show)

@jrbris23, thanks for further details. I'm going to tag @roywalton to bring him into this conversation. He has a lot of information to share about treatment options as he was involved the development and testing of some treatments, including CAR-T and bispecifics.

Your mom is lucky to have you doing that research and advocating for her. How is your mom doing? How are her spirits?

jrbris23 | @jrbris23 | 1 day ago

In reply to @colleenyoung "@jrbris23, thanks for further details. I'm going to tag @roywalton to bring him into this conversation...." + (show)

She is feeling pretty defeated particularly around having been very concerned about being immunocompromised for the past year plus. She just completed all her vaccinations so was feeling more comfortable with seeing family and friends again. She is worried that CAR T will lead to further isolation. Also very concerned about side effects.

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