Latest Signatera test went from negative to 1.02

After chemo, radiation and surgery, I think I had 6 months of Signatera tests that were zero showing no signs of cancer. Then the signatera tests became positive .03, .06, 1.1, 4.2 and up. Scans did not detect any cancer until the 4.2 reading. By the time we did the cryoablation, the Signatera result went to a 15. After the cryoablation I was put back on FOLFOX for 6 rounds. By the 3rd round my Signatera was back to zero. After these 6 rounds they dropped the chemo that causes neuropathy but continued with the other 2 chemo chemicals for another 12 rounds. I have done 4 of these with 8 more to go. The hope is that any residual cells that may try to pop up over a longer term will be killed off with these additional treatments and not become a problem and gone forever. I am on a 2 week Chemo schedule. I don't feel too good after treatments for 4 to 5 days and then start feeling better over that second week. Workwise I do what I can to help out but I am not as directly involved in day to day operations anymore. I have quite a bit of nausea and fatigue for the first week after chemo treatments. Constantly taking the nausea medication helps quite a bit. Hang in there and keep reaching out to people for all the info you can get.

Are you seeking an MRI of lung and abdomen? S+ recurrence (SR) occurred at median > 8 months (mo) prior to radiographic disease, So don't be surprised if an MRI or CT does not pick up the tumor. Suggest you try to find an ecologist who has experienced dealing with S+ cases. Let us know!

Yes I have lots of Signatera info. After my resection my signatera test went from zeros to .03, .06, 1.1, 4.2. My cancer spots did not show up until this time with a 1/4 inch spot on my lung and a 1/2 spot on my liver. I did cryoablation to remove the spots. This procedure is a lot less invasive than radiation or surgery. My signatera went to 15 and we found a couple more spots that were also cryoablated. After this they put me back on chemo and my signatera is back to zero. After 8 treatments, they want me to continue 8 more to hopefully knock out any residual cancer cells that may have been left behind. The unknown is just scary with cancer. Knowing that cancer is coming back with the signatera tests is quite stressful. However, the signatera tests have been very helpful finding cancer spots very early to eliminate and keep from spreading elsewhere. Feel free to message me if you would like more detail or have more questions. It sounds like our cancers are similar but I have a year or so more experience dealing with this stuff. Stay positive! Reid

Yes I have lots of Signatera info. After my resection my signatera test went from zeros to .03, .06, 1.1, 4.2. My cancer spots did not show up until this time with a 1/4 inch spot on my lung and a 1/2 spot on my liver. I did cryoablation to remove the spots. This procedure is a lot less invasive than radiation or surgery. My signatera went to 15 and we found a couple more spots that were also cryoablated. After this they put me back on chemo and my signatera is back to zero. After 8 treatments, they want me to continue 8 more to hopefully knock out any residual cancer cells that may have been left behind. The unknown is just scary with cancer. Knowing that cancer is coming back with the signatera tests is quite stressful. However, the signatera tests have been very helpful finding cancer spots very early to eliminate and keep from spreading elsewhere. Feel free to message me if you would like more detail or have more questions. It sounds like our cancers are similar but I have a year or so more experience dealing with this stuff. Stay positive! Reid

@cjay, @reidroberts Thank you both for your post on your Signatera test results. My prayers are with you both, in your journey. I found your post today as I am 7 months out from surgery for Endometrial Adenocarcinoma Stage IIIC. I did not opt for Chemo after surgery as my immune system was quite low at the time and I needed time to seek help on getting that back on track. I did not want it knocked down any further with Chemo at that point, and they were telling me that they had gotten all of the Cancer during my radical hysterectomy.

My 1st Signatera test came back at 0.00 negative for any CT cells. I was ecstatic to say the least. My CT Scan came back with NED which made me even more encouraged. Meanwhile I have been working with a Naturopath / Nutritionist, and this has helped my immune system tremendously. Unfortunately, my 2nd Signatera test came back with a slight bump up to .07. I wasn't concerned about that because I had read residual cells that were dying off could also cause a reading this low. My 3rd test just came back at .14, another slight bump up, but still positive. My oncologist also did a CA 125 cancer marker test which came back in the low normal range (normal being 0 - 35) and mine was 5.5. I will have another CT Scan in July.

I realize these numbers are very low but I can't find anything on the Signatera Site about when to be concerned. At one point I thought I saw online anything over a 2.0 but now I can't find it. Your conversations concerning your results are very helpful. Could you please tell me how to go about getting a consult with a Signatera Genetic Counselor? I don't think I need it now, but if mine jumps like Reid's did I would like to be able to contact them. I don't seem to be able to find that on the Natera site either.

I appreciate all of the information you have shared and you are both in my prayers.
God Bless,
Kathy

@kkathysan - were you able to contact Natera and speak to a genetic counselor?

Hello 🙂

I’m 10 weeks post surgery ( March 6th).
ovarian 1c2 (and uterine 1a), endometrioid g2. Neg washing’s & lymph’s. Been staying with holistic care and considering carboplatin alone (would start next week).
Got my test back today & it was negative.
Not sure if I should do chemo now 🤔 as I do have worries about chemo AND I am very active with the holistic care (diet, fasting, supplements, off label drugs, IVC, etc)
Anyone have experience with a negative (so early) & then a positive (with similar dx and timeline)? Not sure if I should wait and watch and do chemo later if/ when needed. Or if there is a solid clinical argument that chemo now is hands down the best approach.