I have an immunodeficiency (not autoimmune) like the Boy in the Bubble but not as bad. I do infusions of other people's IgG blood plasma to get their antibodies to fight viruses and bacteria. I am an 83 year old female and still manage to walk 2 miles a day and live in a house with 15 inside stairs. I was diagnosed with osteoporosis in my fifties however my endocrinologist from UCSF that specializes in osteoporosis wouldn't put me on any of the specialized drugs because my immune deficient body may not be able to handle it. I did know a woman that took Fosamax one of the older drugs and lost one side of her jaw. But I will say that both my daughters have osteoporosis and both have been on versions of the newer drugs without problems. But their immune systems are normal.