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@carenr

i was diagnosed with PMR last april, 2024. Was on Preg. 15 mg until Feb, 2025 , and at the same time in Oct. 2024 was put on Methotrexate. In April, my wrists were on fire. The rheumatologist says i have Rheumatoid Arthritis now and put me on low dose preg, and Leflunomide and i am still on the Methotrexate. My blood tests showed negative for RH.
This is getting confusing. has anyone else had these symptoms? thank you

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Replies to "i was diagnosed with PMR last april, 2024. Was on Preg. 15 mg until Feb, 2025..."

Yes, this sounds familiar. When I started to complain about hand and wrist pain and all-day stiffness about six months after PMR diagnosis, my rheumy decided I had seronegative rheumatoid arthritis. I have since changed rheumatologists and had more workup, and she concurs. She says either I was initially misdiagnosed, or have both (overlap syndrome). Late-onset RA (after age 60) usually hits the larger joints first, so is easily confused with PMR. I’ve been on methotrexate for about eight months now and it seems to be helping.

I have wrist/hand and knee pain or stiffness most days. My dr gave me a prescription for Gabapentin in addition to the 15mg Prednisone I was taking but it makes me lightheaded so I stopped taking the Gabapentin. I'd rather have a little pain and feel okay to drive. I was diagnosed about 6 weeks ago. The slight swelling in my wrists has not gone away but it isn't bad enough to affect my activity.

I had wrist and hand pains develop while tapering when I got down to about 7. They continued off and on until I was down below 2. The diagnosis (X-ray) was osteoarthritis that had until then been kept in check (no pain) before PMR by my natural sufficient production of cortisol.
I have been off prednisone now for over two months…no pains. Evidently the cortisol factories are back in production.
Hang in there. Try to keep reducing. If you can deal with some pain while your adrenals resume production, everything might clear up. Otherwise you will be forever reluctant to part with the prednisone. Good luck.