I am trying low-dose Naltrexone and I think it's helping a little. It's hard to tell with Fibro though, because the symptoms come and go like they do, with flares etc. The good thing is no side effects, although some people have sleep issues, and it doesn't help everyone. If you have questions about it, you can find lots of into on-line. It pills must come from a compounding pharmacy because the that aren't sold in the low doses required.