I have pseudomonas colonization. First diagnosed six years ago and initially we hit it pretty hard with PICC line IV antibiotics as well as oral antibiotics. Also began inhaled Tobramycin. (I was also dx'd with MAC and bronchiectasis.) No more PICC line after the first one but occasionally do oral antibiotics if my symptoms become a bother. I am dedicated to twice a day airway clearance using 3% with 7% sodium chloride together. I also use the percussion vest once a day. I have not been on inhaled Tobramycin for a couple of years. Unless they come up with something else that I (or they) feel it is beneficial, I'll stick with this current regime. Best of luck.