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← Return to Waldenstroms Macroglobulemia
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Blood Cancers & Disorders | Last Active: 6 days ago | Replies (23)
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Waldenstroms for goin on two years Imbruvica and prednisone with rituxin stripped working. Bad numbers up good ones down and now severe anemia. Added 10 dexamothosone pills once a week that keep me up for days and I g infusions and concerning
Rituxin and added brukinsa. Doc thinks I have had this much before diagnosis. Due to many unexplained health issue inculdimg thyroid cancer many years again. Anything souls familiar? Am I I. For worse side effects? Is it worth it? I do have faith I. My doctor and I know he is optimistic
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@zeedee1
So sorry to hear about your complications, Zee Dee. But, without knowing your IgM and other "numbers" and symptomology, it's hard to offer suggestions. If you have a CXCR4 mutation type (S338X in particular), which 40% of WM patients have, you are unlikely to respond well to a BTK Inhibitor like Imbruvica or Brukinsa. Prednisone is rarely prescribed for WM (especially long-term), and ususally are used before a major chemo approach (pre-medication) to prevent an infusion reaction. Taking steroids for two years is highly unusual. It can cause weight gain, type-2 diabetes, bone issues, and hypertension. Brukinsa alone is generally well-tolerated. Depending upon your underlying markers Rituxan can be a good fit often teamed up with Bendamustine in the BR protocol if you have a high tumor burden (high IgM loads).